49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high ...

The Jacksonville Jaguars have already clinched a playoff berth. They now face the Indianapolis Colts eyeing improved seeding.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.

Two passes by Darnold to Cooper Kupp and Rashid Shaheed immediately put Seattle into field goal range, but two more ...

The Jacksonville Jaguars pulled off arguably the best win in Week 16, upsetting the Denver Broncos to pull within striking ...

Monday Night Football in Week 16 features a battle between two playoff hopefuls in the San Francisco 49ers and Indianapolis ...

The Indianapolis Colts and 44-year-old QB Phillip Rivers looked sharp at the start against the Jaguars. The Jags defense then ...

Kickoff from Lucas Oil Stadium is set for 1 p.m. ET. Jacksonville is a 6.5-point favorite in the latest Jaguars vs. Colts ...