本研究通过机器学习自动量化UK Biobank中41,212例DXA扫描的胸椎后凸（kyphosis）和腰椎前凸（lordosis）角度，结合GWAS和孟德尔随机化（MR）分析，首次揭示COL11A1、PTHLH等基因通过骨肌稳态和DNA修复通路驱动脊柱曲度衰老，为老年脊柱退行性病变的早期干预提供新靶点。

The spine, or backbone, is made up of small bones (vertebrae) stacked -- along with discs -- one on top of another. A healthy spine, when viewed from the side, has gentle curves to it. The curves help ...