本研究通过BACTH体系和NMR光谱分析，揭示了DDR1和DDR2跨膜域（TMD）的相互作用机制。结果表明，TMD的同型及异型相互作用均由亮氨酸拉链介导，而非GXXXA结构。NMR验证了DDR1TMD与DDR2TMD在膜环境中的稳定结合，系统突变分析进一步确认亮氨酸拉链的关键作用。该发现 ...

The glucocorticoid-induced leucine zipper (GILZ) protein is emerging as a pivotal modulator in inflammation, bridging the anti-inflammatory actions of glucocorticoids (GCs) with downstream immune ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 24 (Dec. 15, 1992), pp. 11779-11783 (5 pages) A distinct family of DNA-binding proteins is characterized ...