The substantia nigra is a motor nucleus located in the basal ganglia of the midbrain. This brain structure contributes to the body's cognitive and motor functions by sending signals to initiate or ...

This perspective argues that Parkinson’s disease may involve functional iron deficiency, where bioavailable iron is limited despite normal or elevated total iron in the brain. The authors propose that ...

Figure 1: Respiratory chain deficiency and analysis of mtDNA deletions in substantia nigra neurons. We then wished to determine the nature of the mtDNA defect within the individual neurons in the ...

水通道蛋白4（AQP4）在帕金森病（PD）病理中起关键作用，其SNpc区域表达下调可加速α-突触核蛋白病理聚集、神经元退变及运动功能障碍。通过shRNA沉默AQP4并在PD模型中注射LC验证，发现AQP4缺失使神经退行加剧，运动障碍进展加快，α-突触核蛋白异常聚集增多。

A new gene therapy targeting the small brain region where dopamine neurons reside, the substantia nigra, substantially boosts the benefits of the drug levodopa in Parkinson's. The therapy restored the ...

Deep in the human brain, a very specific kind of cell dies during Parkinson’s disease. For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into 10 ...