💉 SCIG vs. IVIG: What’s the Difference? 💛 For those with Primary Immunodeficiency (PI), Immunoglobulin (Ig) Replacement Therapy is a crucial treatment—but did you know there are different ways to receive it? ✨ Subcutaneous Immunoglobulin (SCIG): Administered by patients or caregivers at home, ranging from 1–3 times per week to once every two weeks. SCIG is made from plasma and can be given using either a mechanical infusion pump or the push method into the fatty tissue just beneath the skin. ✨